Mister No rescues the famous matador Paco "Jirara" Morales, a fighter for the rights of his Jirara Indian people, from kidnapping. The grateful matador invites Mister No to Pamplona for a vacation, where he will participate in the bullfight at the famous
On the inaccessible Dragon Island, Athos Than organizes a martial arts tournament - an ideal chance for young fighters who would like to prove themselves, and Nathan Never, who is hired by the army to find a deadly bacteriological weapon...
When Mrs. Morales breaks him out of prison and asks him to find her a husband, Mister No will travel to Colombia where he will have to deal with a drug cartel.