A thorny escape from the "Legion of the Undead" brings Mister Noah near the Mexican-American border, where he takes a job as a gravedigger, but it is known that he cannot stay out of trouble for long.
Jerry Drake finds himself in Redención, a fictitious Mexican town ruled by the evil El Jefe and his equally depraved son Diego. Diego holds Barret Whitaker, Jerry's friend, captive in order to lure him into a trap...
When Mrs. Morales breaks him out of prison and asks him to find her a husband, Mister No will travel to Colombia where he will have to deal with a drug cartel.
Mister No is hired by anthropologist Prof. Ribeiro and his assistant Saraj Moraes to escort them to a mission in the Catrimani Indian village. In the village, they are greeted by a tribe afflicted with a mysterious disease...