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Heiress of the Florentine Medici line, Lucrezia marries the Duke of Ferrara, a supporter of Alfonso d'Este. The marriage is full of difficulties from the beginning and, as time passes, Lucrezia becomes more and more estranged from her husband. Alfonso, on the other hand, is under increasing pressure from the Vatican, which threatens to deprive him of his title if he is not able to provide himself with a successor. Only Alfonso's lover Francesca seems to be able to contain his suppressed rage. The revulsion towards his young wife soon becomes unbearable and Alfonso begins to think of a way to escape from his problems...