Mister No is hired by anthropologist Prof. Ribeiro and his assistant Saraj Moraes to escort them to a mission in the Catrimani Indian village. In the village, they are greeted by a tribe afflicted with a mysterious disease...
Together with Chico and Trampi, Zagor helps Pickens free his wife, and eventually clashes with the kidnappers, where he meets the titular Mr. Smith, a strange man who is in fact the real reason for all this complication.
The dark shadow of the Eagle King looms over the little tribe of Munsee Indians! And while the Miwok chief fears for the life of his abducted son Bijeli Jelen, Zagor and Chico embark on a rescue operation...